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. Author manuscript; available in PMC: 2013 Jan 25.
Published in final edited form as: J Am Chem Soc. 2012 Jan 10;134(3):1673–1679. doi: 10.1021/ja2087147

Table 2.

Competition assay of geldanamycin-FITC conjugate (10 nM) bound to Hsp90α (50 nM) with geldanamycin derivatives 5b, 8 – 12. The IC50 values obtained from dose-response fitting curves as a function of the competitor concentration are given in the table.18

Geldanamycin derivative
GMFICT 5b 8 9 10 11 12
Fluorescence polarization [nM] 2.3±0.1 8±6 42±7 95±8 256±84 19±4 24±3