Figure 3.

Risk-benefit acceptability curves for anticoagulants used for venous thromboembolism prophylaxis in orthopedic surgery compared to placebo for all patients (A), total hip replacement patients (B) and total knee replacement patients (C). The curves show for each anticoagulant the probability of being net risk-beneficial compared to placebo across different risk-benefit acceptability thresholds which reflect the willingness to accept the risk of major bleeding episodes. The reference value is shown as the vertical dashed line with the 95% confidence interval shown as the shadowed area. Note that these curves do not allow a comparison of all agents simultaneously and do not inform the option with the best risk-benefit profile.