Table 1.

Pooled estimates of proportions for risk and benefit outcomes in studies evaluating the use of anticoagulant prophylaxis for venous thromboembolism in orthopedic surgery

Drug	Major Venous Thromboembolism		Major Bleeding
	% (95% CI)	Variance	% (95% CI)	Variance
All patients
Ximelagatran	3.274 (3.175, 3.372)	0.098	1.804 (1.722, 1.885)	0.082
LMWH	6.528 (6.357, 6.699)	0.171	2.208 (2.156, 2.260)	0.052
UFH	13.394 (12.862, 13.926)	0.532	2.494 (2.363, 2.625)	0.131
Warfarin	6.278 (6.092, 6.463)	0.186	1.778 (1.690, 1.867)	0.088
Fondaparinux	2.051 (1.957, 2.146)	0.094	5.113 (4.690, 5.536)	0.423
Placebo	21.019 (19.978, 22.060)	1.041	1.781 (1.651, 1.912)	0.130
Total hip replacement
Ximelagatran	3.401 (3.181, 3.621)	0.220	2.892 (2.683, 3.101)	0.209
LMWH	6.472 (6.293, 6.651)	0.179	2.151 (2.085, 2.216)	0.066
UFH	15.154 (14.446, 15.862)	0.708	2.813 (2.625, 3.001)	0.188
Warfarin	4.280 (4.083, 4.477)	0.197	2.229 (2.088, 2.371)	0.141
Fondaparinux	2.138 (2.009, 2.267)	0.129	6.033 (5.501, 6.566)	0.532
Placebo	24.726 (23.268, 26.184)	1.458	1.463 (1.299, 1.628)	0.164
Total knee replacement
Ximelagatran	3.100 (3.042, 3.158)	0.058	1.127 (1.095, 1.159)	0.032
LMWH	5.143 (5.010, 5.277)	0.134	1.605 (1.566, 1.644)	0.039
UFH	9.119 (8.803, 9.436)	0.316	0.943 (0.837, 1.050)	0.106
Warfarin	8.100 (7.879, 8.322)	0.221	0.822 (0.792, 0.852)	0.030
Fondaparinux	2.446 (2.288, 2.603)	0.158	2.128 (2.003, 2.252)	0.124
Placebo	14.833 (14.351, 15.314)	0.482	2.116 (1.911, 2.322)	0.205

VTE Venous thromboembolism; CI Confidence interval; LMWH Low molecular weight heparin; UFH Unfractionated heparin.