Table 4.
Kaplan-Meier analyses of all parameters with median survival and 95% confidence interval before and 24 h after SIRT
| Biomarker | Time | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median survival [months] | 95% Confi. Interval | Median survival [months] | 95% Confi. Interval | Median survival [months] | 95% Confi. Interval | Median survival [months] | 95% Confi. Interval | Log-rank | ||
| Nucleosomes [ng/mL] | 0 h | < 83 | 83-190 | 191-415 | > 415 | 0.1275 | ||||
| 17.3 | 1.5 - | 8.2 | 4.6 - | 13.8 | 3.2-23.8 | 6.0 | 1.5-15.4 | |||
| 24 h | < 384 | 384-751 | 752-1232 | > 1232 | 0.0004 | |||||
| 23.8 | 4.9-23.8 | 8.0 | 2.5 - | 13.8 | 4.0-20.6 | 5.1 | 1.4-6.1 | |||
|
CYFRA 21-1 [ng/mL] |
0 h | < 5.3 | 5.3-10.0 | 10.0-32 | > 32.8 | < .0001 | ||||
| 20.6 | 8.2 - | 4.9 - | 7.0 | 2.8-18.8 | 3.1 | 1.4-5.1 | ||||
| 24 h | < 13 | 13-28 | 29-74 | > 74 | 0.0009 | |||||
| 20.6 | 8.2-23.8 | 6.3 | 3.4 - | 6.2 | 3.1 - | 4.6 | 1.4-15.0 | |||
|
CEA [U/L] |
0 h | < 55 | 55-320 | 321-1041 | > 1041 | 0.0002 | ||||
| 20.6 | 3.1 - | 19.6 | 5.6 - | 8.3 | 4.2-18.8 | 3.1 | 1.4-6.1 | |||
| 24 h | < 85 | 85-351 | 352-982 | > 982 | 0.0002 | |||||
| 20.6 | 8.2-23.8 | 19.6 | 4.2 - | 5.5 | 2.5-8.8 | 4.9 | 1.5-15.0 | |||
|
CA 19-9 [U/L] |
0 h | < 10 | 10-40 | 41-285 | > 285 | 0.0006 | ||||
| 15.0 | 3.1 - | 23.8 | 8.2 - | 6.6 | 2.8 - | 4.9 | 1.4-6.2 | |||
| 24 h | < 10 | 10-48 | 49-285 | > 285 | 0.0096 | |||||
| 15.4 | 3.1 - | 17.8 | 4.2-23.8 | 6.6 | 2.8 - | 5.5 | 1.4-11.0 | |||
|
CRP [mg/dL] |
0 h | < 0.5 | 0.5-1.3 | 1.4-8.3 | > 8.3 | < .0001 | ||||
| 23.8 | 19.6 - | 14.4 | 3.4 - | 6.8 | 4.4-15.0 | 3.1 | 1.4-5.1 | |||
| 24 h | < 0.7 | 0.7-1.3 | 1.4-6.4 | > 6.4 | < .0001 | |||||
| 23.8 | 11.0-23.8 | 4.7 - | 8.8 | 5.8-15.4 | 3.0 | 1.4-5.1 | ||||
|
LDH [U/L] |
0 h | < 299 | 299-393 | 394-604 | > 604 | < .0001 | ||||
| 20.6 | 8.2 - | 15.4 | 4.7 - | 8.8 | 1.5-23.8 | 3.2 | 1.5-5.0 | |||
| 24 h | < 336 | 336-486 | 487-878 | > 878 | 0.0002 | |||||
| 23.8 | 8.2 - | 11.0 | 4.4 - | 6.8 | 4.6-16.8 | 2.8 | 1.4-15.0 | |||
|
AST [U/L] |
0 h | < 35 | 35-52 | 53-66 | > 66 | < .0001 | ||||
| 20.6 | 15.0 - | 13.8 | 5.0 - | 7.3 | 4.6-15.0 | 3.0 | 1.4-4.2 | |||
| 24 h | < 48 | 48-74 | 75-135 | > 135 | 0.0004 | |||||
| 11.0 - | 6.3 | 4.6-19.6 | 5.6 | 2.8-15.4 | 3.4 | 1.5-15.0 | ||||
|
ALT [U/L] |
0 h | < 26 | 26-34 | 35-50 | > 50 | 0.0773 | ||||
| 18.8 | 5.2 - | 7.8 | 3.1 - | 13.8 | 5.1-15.4 | 3.8 | 1.5-23.8 | |||
| 24 h | < 30 | 30-46 | 47-64 | > 64 | 0.0824 | |||||
| 20.6 | 5.2 - | 5.5 | 4.4-15.0 | 15.0 | 2.6-19.6 | 4.1 | 1.5 - | |||
|
CHE [kU/L] |
0 h | < 5.8 | 5.8-7.3 | 7.4-8.4 | > 8.4 | 0.0013 | ||||
| 5.1 | 1.5-6.2 | 5.9 | 2.8 - | 8.2 | 4.0-19.6 | 28.8 | 11.0-23.8 | |||
| 24 h | < 5.1 | 5.1-6.3 | 6.4-7.6 | > 7.6 | 0.0002 | |||||
| 4.7 | 1.4-6.8 | 5.4 | 2.5-20.6 | 23.8 | 4.4 - | 18.8 | 8.2 - | |||
|
GGT [U/L] |
0 h | < 110 | 110-183 | 184-282 | > 282 | 0.0034 | ||||
| 16.7 | 5.9 - | 18.8 | 4.4-20.6 | 11.0 | 2.8-15.4 | 4.4 | 2.5-7.8 | |||
| 24 h | < 94 | 94-165 | 166-274 | > 274 | 0.0101 | |||||
| 17.3 | 6.8 - | 12.5 | 4.4-20.6 | 15.0 | 2.8 - | 4.8 | 2.5-7.8 | |||
|
AP [U/L] |
0 h | < 114 | 114 - 160 | 161 - 321 | > 321 | < .0001 | ||||
| 20.6 | 8.2 - | 18.8 | 4.6 - 23.8 | 6.2 | 3.2 - | 4.2 | 1.5 - 5.5 | |||
| 24 h | < 98 | 98 - 148 | 149 - 265 | > 265 | < .0001 | |||||
| 23.8 | 8.2 - | 13.8 | 4.6 - 19.6 | 7.8 | 3.4 - 18.8 | 3.7 | 4.1 - 6.2 | |||
| Bilirubin [mg/dL] | 0 h | < 0.5 | 0.5 - 0.7 | 0.8 - 1.2 | > 1.2 | 0.2393 | ||||
| 14.4 | 4.4 - | 11.0 | 2.8 - | 18.8 | 5.1 - | 4.4 | 1.5 - 15.0 | |||
| 24 h | < 0.8 | 0.8 - 1.0 | 1.1 - 1.8 | > 1.8 | 0.3335 | |||||
| 10.3 | 4.0 - 19.6 | 15.4 | 4.6 - | 5.9 | 2.5 - | 8.2 | 1.5 - 23.8 | |||
|
Amylase [U/L] |
0 h | < 44 | 44 - 58 | 59 - 75 | > 75 | 0.0102 | ||||
| 5.2 | 1.4 - 18.8 | 7.5 | 3.2 - 19.6 | 17.4 | 2.5 - 23.8 | 5.8 - | ||||
| 24 h | < 35 | 35 - 44 | 44 - 63 | > 63 | 0.0030 | |||||
| 5.2 | 3.2 - 15.4 | 6.2 | 3.1 - | 15.0 | 2.8 - | 20.6 | 1.5 - | |||
|
Lipase [U/L] |
0 h | < 13 | 13 - 26 | 27 - 38 | > 38 | 0.5314 | ||||
| 5.7 | 1.5 - | 18.8 | 2.8 - | 8.8 | 4.0 - | 13.0 | 3.4 - 19.6 | |||
| 24 h | < 10 | 10- 18 | 18 - 28 | > 28 | 0.6226 | |||||