Table 3.
Risk of low-grade squamous intraepithelial neoplasia (LSIL) diagnosis at each visit given vaginal pH measurement, stratified by age at visit
| Vaginal pH Level | N | Percent with LSIL | Odds of LSIL Cytologya (95% CI) | p-value |
|---|---|---|---|---|
| All Womenb | ||||
| 4.0-4.5 | 19,272 | 2.4 | ref | < 0.01 |
| 5.0-5.5 | 9,059 | 2.5 | 1.3 (1.1-1.6) | |
| Age at Visit | ||||
| < 25 years | ||||
| 4.0-4.5 | 1,536 | 4.0 | ref | 0.12 |
| 5.0-5.5 | 475 | 5.7 | 1.5 (0.9-2.3) | |
| 25-34 years | ||||
| 4.0-4.5 | 6,178 | 2.9 | ref | 0.02 |
| 5.0-5.5 | 1,721 | 4.0 | 1.4 (1.0-1.9) | |
| 35-44 years | ||||
| 4.0-4.5 | 6,074 | 2.3 | ref | 0.30 |
| 5.0-5.5 | 1,568 | 2.8 | 1.2 (0.9-1.7) | |
| 45-54 years | ||||
| 4.0-4.5 | 3,216 | 1.9 | ref | 0.33 |
| 5.0-5.5 | 1,776 | 2.3 | 1.2 (0.8-1.8) | |
| 55-64 years | ||||
| 4.0-4.5 | 1,308 | 1.3 | ref | 0.82 |
| 5.0-5.5 | 1,653 | 1.4 | 1.1 (0.6-1.9) | |
| 65+ years | ||||
| 4.0-4.5 | 960 | 0.5 | ref | 0.04 |
| 5.0-5.5 | 1,866 | 1.4 | 2.7 (1.0-7.0) | |
a Generalized estimating equation models with an independent correlation structure were used to estimate the odds of testing positive LSIL given dichotomous pH measurements at each visit
b Adjusted for age at visit