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. 2011 Dec 20;11:523. doi: 10.1186/1471-2407-11-523

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Copyright ©2011 Matsuura et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nuclear localization of YAP1 is frequently detectable in ccRCCs with SAV1 downregulation. Immunohistochemistry of ccRCC tissues using anti-SAV1 antibody and anti-YAP1 antibody (×400). Representative results are shown. YAP1 tends to be localized in the nucleus of tumor cells in cases showing downregulation of SAV1 (case #96), whereas it tends to be localized mainly in the cytoplasm of tumor cells without downregulation of SAV1 (case #84). The cytoplasm of endothelial cells is positively immunostained. No positive staining is detectable in both cases using normal mouse IgG as the primary antibody (IgG).