Table 1.

The protein-like properties of sequence evolution over simulation time is shown

Simulation time	Model	Core	Surface	Gamma Support	Shape Parameter
		Hydrophobicity	Hydrophobicity
		(%)	(%)
5000	Informational	39.7	11.2	0.35	0.02
25000	Informational	42.1	15.2	0.72	0.95
50000	Informational	42.9	18.5	0.72	1.46
70000	Informational	45.0	20.4	0.69	1.55
100000	Informational	47.4	23.0	0.73	2.07
150000	Informational	47.7	27.7	0.49	2.61
200000	Informational	49.6	30.5	0.12	2.73
5000	Physics-based	83.4	49.2	0.20	3.31
25000	Physics-based	82.8	49.5	0.37	2.58
50000	Physics-based	81.7	49.1	0.31	2.06
70000	Physics-based	81.7	48.4	0.61	1.86
100000	Physics-based	81.1	48.6	0.09	1.87
150000	Physics-based	81.6	48.2	0.25	1.76
200000	Physics-based	81.1	48.0	0.10	1.88

Simulation time is listed in generations. Core and surface hydrophobicities shown reflect the population average percentage of hydrophobic residues in buried and exposed positions. Gamma support indicates the fractional support for a model including a gamma distribution of rates, and the shape parameter shows the α value of such a distribution.