Table 3.
Metabolic fluxes corresponding to the best fit of experimental data and their 99% confidence intervals
| Glucose as the only substrate | Glucose with lactate | ||
|---|---|---|---|
| 99% confidence interval | 99% confidence interval | ||
| bestfit (min - max) | bestfit (min - max) | Model A | |
| hk1 | 0.0026894(0.002150-0.003080) | 0.152266(0.074815-0.377413) | 0.01981 |
| hk2 | 0.0021436(0.001710-0.002480) | 0.0056939(0.0041563-0.0076078) | |
| g6pase1 | 5.50E-05(2.70E-5-7.80E-5) | 0.150611(0.073125-0.375565) | 0.01809 |
| g6pase2 | 2.13E-05(0.0-0.000066) | 0.005166(0.0029064-0.0071982) | |
| pfk1 | 0.003048(0.002370-0.003530) | 0.0023558(0.0015063-0.0046942) | 0.00345 |
| pfk2 | 0.0004816(0.0-0.000950) | 0.0007975(0.0006197-0.0012778) | |
| fbpase1 | 0.0004446(0.000270-0.000560) | 0.0013469(0.0005781-0.0023709) | 0.00363 |
| fbpase2 | 0.0005496(0.000330-0.000690) | 0.0023329(0.00161-0.0032427) | |
| gp | 2.56E-06(1.70E-6-5.10E-6) | 0.000143(5.12E-05-0.0001883) | 0.00000 |
| gs | 0.0021929(0.001660-0.002680) | 0.0022087(0.0018593-0.0027097) | 0.00188 |
| aldf | 0.0192413(0.007480-0.022580) | 0.0159083(0.0153142-0.0163931) | 0.01608 |
| aldr | 0.016706(0.004480-0.020410) | 0.0164349(0.0153054-0.016708) | 0.01625 |
| aldex | 0.0424386(0.010420-0.056150) | 0.0137425(0.0103922-0.0195718) | 0.01565 |
| g3pep | 0.0064103(0.004490-0.007700) | 0.258278(0.1677705-0.3394195) | 0.12224 |
| pepg3 | 0.0013391(0.000140-0.002370) | 0.258701(0.166264-0.339572) | 0.12257 |
| pk | 0.0050704(0.003910-0.006230) | 0.0199774(0.0157079-0.0239355) | 0.01497 |
| lacin | 1.71E-07(1.20E-7-2.60E-7) | 0.231716(0.1714965-0.2686475) | 0.12266 |
| lacout | 0.00507(0.003910-0.006230) | 0.222326(0.1621185-0.2590095) | 0.11074 |
| pc | 1.20E-07(5.70E-8-1.90E-7) | 0.0204457(0.0155337-0.0233495) | 0.01542 |
| pepck | 1.16E-08(5.30E-9-2.80E-8) | 0.020401(0.0154933-0.0232863) | 0.01530 |
| maloa | 1.85E-07(9.60E-8-3.00E-7) | 0.0835934(0.048937-0.111892) | 0.03396 |
| oamal | 3.80E-08(1.30E-8-8.10E-8) | 0.0747156(0.0368199-0.0997713) | 0.02261 |
| cs | 2.55E-07(1.30E-7-4.00E-7) | 0.008922(0.0069631-0.0147641) | 0.01147 |
| citmal | 1.47E-07(8.40E-8-2.30E-7) | 0.0088778(0.0069227-0.0146991) | 0.01135 |
| pdh | 2.75E-07(7.70E-8-5.00E-7) | 0.0089212(0.0069623-0.0147633) | 0.01147 |
| g6pdh | 3.87E-06(2.80E-6-7.50E-6) | 0.0018986(0.0013506-0.0021492) | 0.00000 |
| p5p > s7p | 0.0011849(0.000880-0.002270) | 0.0006229(0.0004459-0.0007215) | 0.00051 |
| s7p > r5p | 0.0011925(0.000890-0.002280) | 4.35E-06(2.56E-06-2.98E-05) | 0.00047 |
| f6p > p5p | 9.59E-06(4.20E-6-3.40E-5) | 4.02E-05(1.17E-05-9.84E-05) | 0.00000 |
| p5p > f6p | 4.93E-06(2.80E-6-2.80E-5) | 0.0006793(0.0004937-0.000751) | 0.00000 |
| f6p > s7p | 1.85E-05(9.20E-6-7.30E-5) | 1.40E-05(4.56E-06-2.45E-05) | 0.00000 |
| s7p > f6p | 9.56E-06(4.80E-6-6.60E-5) | 1.65E-06(9.03E-07-8.56E-06) | 0.00000 |
| p5p-g3p | 0.0006152(2.70E-4-2.83E-3) | 0.0017868(0.0007706-0.0033249) | 0.00036 |
| f6p-s7p | 7.69E-08(2.10E-8-7.70E-7) | 1.53E-05(4.62E-06-2.78E-05) | 0.00000 |
| p5p-s7p | 0.0022967(1.37E-3-7.06E-3) | 1.51E-06(8.37E-07-8.16E-06) | 0.00067 |
| f6p > s7p | 0.0015144(0.000850-0.001940) | 0.000862(0.0002796-0.0021263) | 0.00117 |
| s7p-f6p | 0.0015015(0.000850-0.001920) | 0.0014894(0.0008194-0.0026708) | 0.00119 |
| f6p-g3p | 0.0075338(0.002170-0.013330) | 0.0164459(0.0085357-0.0352201) | 0.00230 |
| s7p-e4p | 0.0003018(0.000140-0.000550) | 7.81E-05(2.01E-05-0.0002102) | 0.00061 |
The names of fluxes are given in the list of abbreviations in the text.