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. 2012 Mar 2;7(3):e32429. doi: 10.1371/journal.pone.0032429

Figure 1. Endothelial-specific deletion of Nrp1 causes DiGeorge syndrome defects in E18 mice.

Figure 1

A,B, Whole mount views of the outflow region of the heart. The Tie2Cre/Nrp1 mutant (B) has a common arterial trunk (CAT) and lacks the arch of the aorta (aAo). Other abbreviations: Ao, ascending aorta; lca, left carotid artery; PT, pulmonary trunk; rca, right carotid artery. C, Thymuses from two control embryos (at left) and two mutant embryos (at right), all from the same litter. D, Quantification of thymic volumes at E18 (n = 6 for each sample). E,F, Transverse sections showing the thyroid (t) and parathyroid (arrows; the parathyroids are also shown in Fig. S1B–C) in a control (E) and mutant (F). G,H, Whole mount view of the palate to show clefting (arrows) in the mutant (H).