Table 2. Correlations between betaine, dimethylglycine and homocysteine in the two populations.
| Plasma dimethylglycine (µmol/L) | Plasma homocysteine (µmol/L) | Betaine excretion (mmol/mole) | Dimethylglycine excretion (mmol/mole) | |
| A. ACS study | ||||
| Plasma betaine (µmol/L) | ||||
| r = | +0.26 | −0.06 | +0.027 | −0.016 |
| p = | <0.00001 | 0.15 | 0.59 | 0.75 |
| n = | 523 | 510 | 393 | 393 |
| Plasma dimethylglycine (µmol/L) | ||||
| r = | +0.25 | +0.05 | +0.16 | |
| p = | <0.00001 | 0.33 | 0.0013 | |
| n = | 510 | 393 | 393 | |
| Plasma homocysteine (µmol/L) | ||||
| r = | +0.019 | +0.017 | ||
| p = | 0.70 | 0.74 | ||
| n = | 402 | 402 | ||
| Betaine excretion (mmol/mole) | ||||
| r = | +0.54 | |||
| p = | <0.00001 | |||
| n = | 415 | |||
| B. Lipid clinic study | ||||
| Plasma betaine (µmol/L) | ||||
| r = | +0.25 | −0.02 | +0.08 | −0.10 |
| p = | 0.0017 | 0.77 | 0.30 | 0.22 |
| n = | 158 | 158 | 158 | 158 |
| Plasma dimethylglycine (µmol/L) | ||||
| r = | 0.0076 | +0.03 | +0.03 | |
| p = | +0.21 | 0.69 | 0.67 | |
| n = | 158 | 158 | 158 | |
| Plasma homocysteine (µmol/L) | ||||
| r = | +0.35 | +0.29 | ||
| p = | <0.00001 | 0.0002 | ||
| n = | 158 | 158 | ||
| Betaine excretion (mmol/mole) | ||||
| r = | +0.59 | |||
| p = | <0.00001 | |||
| n = | 158 |
Pearson's correlation coefficients calculated using log-transformed data. Plasma betaine and dimethylglycine concentrations corrected for gender difference. Excretions measured as mmole/mole creatinine. Significant correlations in bold.