Table 3. Correlations in ACS subjects split on median betaine excretion.
Plasma dimethylglycine (µmol/L) | Plasma homocysteine (µmol/L) | Betaine excretion (mmol/mole) | Dimethylglycine excretion (mmol/mole) | |
A. Above median betaine excretion | ||||
Plasma betaine (µmol/L) | ||||
r = | +0.23 | −0.07 | −0.05 | −0.015 |
p = | 0.0015 | 0.36 | 0.50 | 0.84 |
n = | 194 | 193 | 194 | 194 |
Plasma dimethylglycine (µmol/L) | ||||
r = | +0.23 | −0.03 | +0.27 | |
p = | 0.0016 | 0.72 | 0.0001 | |
n = | 193 | 194 | 194 | |
Plasma homocysteine (µmol/L) | ||||
r = | +0.10 | +0.07 | ||
p = | 0.14 | 0.29 | ||
n = | 194 | 194 | ||
Betaine excretion (mmol/mole) | ||||
r = | +0.39 | |||
p = | <0.00001 | |||
n = | 208 | |||
B. Below median betaine excretion | ||||
Plasma betaine (µmol/L) | ||||
r = | +0.23 | −0.012 | +0.015 | −0.07 |
p = | 0.001 | 0.87 | 0.84 | 0.33 |
n = | 200 | 192 | 200 | 200 |
Plasma dimethylglycine (µmol/L) | ||||
r = | +0.24 | −0.12 | +0.024 | |
p = | 0.0009 | 0.096 | 0.74 | |
n = | 192 | 200 | 200 | |
Plasma homocysteine (µmol/L) | ||||
r = | −0.17 | −0.056 | ||
p = | 0.019 | 0.44 | ||
n = | 199 | 199 | ||
Betaine excretion (mmol/mole) | ||||
r = | +0.23 | |||
p = | 0.0007 | |||
n = | 208 |
Pearson's correlation coefficients calculated using log-transformed data. Plasma betaine and dimethylglycine concentrations corrected for gender difference. Excretions measured as mmole/mole creatinine. Significant correlations in bold.