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. 2012 Mar 2;7(3):e32460. doi: 10.1371/journal.pone.0032460

Table 3. Correlations in ACS subjects split on median betaine excretion.

Plasma dimethylglycine (µmol/L) Plasma homocysteine (µmol/L) Betaine excretion (mmol/mole) Dimethylglycine excretion (mmol/mole)
A. Above median betaine excretion
Plasma betaine (µmol/L)
r =  +0.23 −0.07 −0.05 −0.015
p =  0.0015 0.36 0.50 0.84
n =  194 193 194 194
Plasma dimethylglycine (µmol/L)
r =  +0.23 −0.03 +0.27
p =  0.0016 0.72 0.0001
n =  193 194 194
Plasma homocysteine (µmol/L)
r =  +0.10 +0.07
p =  0.14 0.29
n =  194 194
Betaine excretion (mmol/mole)
r =  +0.39
p =  <0.00001
n =  208
B. Below median betaine excretion
Plasma betaine (µmol/L)
r =  +0.23 −0.012 +0.015 −0.07
p =  0.001 0.87 0.84 0.33
n =  200 192 200 200
Plasma dimethylglycine (µmol/L)
r =  +0.24 −0.12 +0.024
p =  0.0009 0.096 0.74
n =  192 200 200
Plasma homocysteine (µmol/L)
r =  −0.17 −0.056
p =  0.019 0.44
n =  199 199
Betaine excretion (mmol/mole)
r =  +0.23
p =  0.0007
n =  208

Pearson's correlation coefficients calculated using log-transformed data. Plasma betaine and dimethylglycine concentrations corrected for gender difference. Excretions measured as mmole/mole creatinine. Significant correlations in bold.