Rate dependence on delay time between addition of water and 3d. Plot of the rates of hydrolysis of (R)-1,2-epoxyhexane ([epoxide]i = 5.4 M) in 1,2-hexanediol versus conversion of water ([H2O]i = 3.1 M) in 1,2-hexanediol. In each experiment, (S,S)-(salen)Co–Cl (0.15 mol %) was added to the reaction mixture and aged for 45 min, followed by water; 3d (0.15 mol %) was added as a solution in CH2Cl2 subsequently after the indicated delay time. The black curve is derived from an experiment in which neither 3d nor CH2Cl2 was added.