Rate dependence on the time between addition of (salen)Co–OTs and water to a solution of epoxide. Plot of the rates of hydrolysis of (S)-1,2-epoxyhexane ([epoxide]i = 5.4 M) in 1,2-hexanediol versus conversion of water ([H2O]i = 3.1 M) in 1,2-hexanediol. In each experiment, (R,R)-(salen)Co–OTs (0.15 mol %) was added to the reaction mixture as an 83 mM CH2Cl2 solution; water was added subsequently after the indicated delay time.