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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Cell Physiol. 2012 Jul;227(7):2907–2916. doi: 10.1002/jcp.23035

Figure 6.

Figure 6

Paracrine effects of native EPCs and PGI2-EPCs on 4-aminopyridine–sensitive K+ current of rat smooth muscle cells (rSMCs) under normoxia and hypoxia. (A) Representative current traces were elicited by depolarizing voltage pulses (4 s) between −70 and +60 mV (10 mV steps) from a holding potential of −80mV under normoxic and hypoxic conditions. (B) Average data showing current-voltage (I–V) relationships. (C) Summarized data showing current amplitudes at 60 mV (n=9). **P<0.01 compared with rSMCs cocultured with native EPCs. (D) Representative current traces were recorded from rSMCs after coculture with PGI2-EPCs treated with PGIS siRNA or PGI2-EPCs treated with control siRNA under hypoxia. (E) The current-voltage (I–V) relationships (n=9). *P<0.05 compared with rSMCs cocultured with PGI2-EPCs treated with PGIS siRNA.