Table 1.
Serum antibody and virus titers after homologous challenge.
| Vaccine Group | Mean Virus Titer (log10 TCID50/ml) [#(+)/total] | Mean Serum HAI Antibody Titer (range) | ||
|---|---|---|---|---|
| 3 dpca | 5 dpc | SD-LAIV 14 dpvb |
wtSD 17 dpc |
|
| Aerosol 107 | <1c | <1 | 587 (320–640) | 640 |
| i.n. 107 | <1 | <1 | 427 (320–640) | 853 (640–1280) |
| Aerosol 103 | <1 | <1 | 160 | 533 (320–640) |
| i.n. 103 | 1.6±0.58 (1/3) | <1 | 160 | 640 (320–1280) |
| Aerosol PBS | 4.2± 0.15 (3/3) | 4.4±0.40 (3/3) | <10 | 1920 (1280–2560) |
a
days post challenge with wtSD; n=3/group
b
days post vaccination with SD-LAIV; n=3/group
c
limit of detection