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Mitochondrial fission. Drp1 and Fis1 promote mitochondrial fission, the process by which a single organelle is cleaved into two or more daughter mitochondria. Drp1 is usually present in the cytoplasm as oligomers, but is recruited to the outer mitochondrial membranes by interaction with FIS1. Once at the membrane, oligomers assemble into larger complexes where they promote GTPase dependent remodeling and fission of the membrane.
