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Regulation of mitophagy by PINK1. PINK1-dependent mitophagy requires the accumulation of full-length (FL) PINK1 on the outer mitochondrial membrane that recruits parkin to mediate selective mitophagy through increased ubiquitination of substrates, including Mfn2. PINK1 and can also bind beclin1 to promote autophagy through the class III PI3 kinase VPS34 and p150.
