FIG. 7.

Genes associated with autosomal dominant parkinsonism. Diagrams of the domain organization of dominant mutations not drawn to scale are shown. LRRK2 is a large multidomain protein. The N-terminal region contains Ankyrin (ANK) and Leucine-rich repeats (LRR). Following the repeats is the core catalytic region of the protein containing a GTP-binding Ras of complex protein (Roc) domain, a carboxy-terminal of Roc (COR) domain, and a kinase domain. Following the kinase domain is a C-terminal WD40 domain ending before a short C-terminal tail. The N-terminal region of α-synuclein is important for membrane association and is composed of imperfect repeats of KTEGV. The next region of α-synuclein is hydrophobic NAC (nonamyloid component) region, followed by an unstructured C-terminal acidic tail.