Table 2.
Hazard Ratio Analysis of Demographic and Virological Parameters with HIV Disease Progression
| Univariate HR (95% CI) | p-value | Multivariate HR (95% CI) | p-value | |
|---|---|---|---|---|
| Age at seroconversion | 1.04 (1.01–1.07) | 0.006 | Excluded | — |
| Female gender | 1.08 (0.69–1.67) | 0.746 | — | — |
| Viral load set point | 1.51 (1.07–2.12) | 0.019 | 1.49 (1.01–2.19) | 0.045 |
| Baseline CCR5-UE | 1.15 (0.91–1.45) | 0.249 | — | — |
| X4 emergence | 1.83 (1.01–3.32) | 0.045 | 1.69 (0.88–3.23) | 0.112 |
| Subtype A vs. D | 0.53 (0.30–0.92) | 0.024 | 0.66 (0.36–1.19) | 0.164 |
| Subtype A vs. R | 0.56 (0.28–1.10) | 0.091 | — | — |
95% confidence intervals (CI) are shown in parentheses. HR, hazard ratio. CCR5-UE: utilization efficiency of viral replication on CCR5-bearing cells in the Trofile assay. X4 emergence: detection of CXCR4-using viruses. Viral load set point was defined as the viral load measured in the first sample collected after HIV seroconversion. Statistically significant associations are shown in bold and were determined at p<0.05. Age was excluded since it has a disproportionate effect on disease progression.