Table 1.
Characteristics of Vertically HIV-Infected Children at Enrollment and at the First Opportunistic Infection After Enrollment on NISDI
| Study variable | At enrollment N=731 (%) | Experiencing an OI on study N=383 (%) |
|---|---|---|
| Country of birth | ||
| Brazil | 483 (66.1) | 285 (74.4) |
| Mexico | 118 (16.1) | 45 (11.8) |
| Argentina | 71 (9.7) | 22 (5.7) |
| Peru | 37 (5.1) | 20 (5.2) |
| Jamaica | 22 (3.0) | 11 (2.9) |
| Gender | ||
| Male | 325 (44.5) | 174 (45.4) |
| Female | 406 (55.5) | 209 (54.6) |
| Age (years) | ||
| Median (QR) | 5.0 (3.0–9.0) | 6.0 (4.0–10.0) |
| <1 | 37 (5.1) | 11 (2.9) |
| 1-4 | 275 (37.6) | 113 (29.5) |
| 5-9 | 280 (38.3) | 160 (41.8) |
| ≥10 | 139 (19.0) | 99 (25.8) |
| HIV classification (CDC) | ||
| N | 101 (14.0) | 39 (10.3) |
| A | 155 (12.5) | 76 (20.1) |
| B | 233 (32.3) | 128 (33.9) |
| C | 233 (32.3) | 135 (35.7) |
| Missinga | 9 | 5 |
| ARV regimen | ||
| PI + NNRTI HAART | 55 (7.5) | 14 (3.6) |
| PI HAART | 328 (44.9) | 186 (48.6) |
| NNRTI HAART | 103 (14.1) | 63 (16.4) |
| Other ARV | 127 (17.4) | 75 (19.6) |
| No ARV | 118 (16.1) | 45 (11.8) |
| CD4 percent | ||
| Median (QR) | 27% (21–34) | 26% (19–34) |
| <15% | 74 (11.5) | 49 (14.1) |
| 15–24% | 187 (29.0) | 102 (29.4) |
| ≥25% | 384 (59.5) | 196 (56.5) |
| Missinga | 86 | 36 |
| HIV viral load (copies/ml) | ||
| Median (QR) | 7.9K (0.2–44.3K) | 10.5K (0.7–63K) |
| <1000 | 225 (31.0) | 100 (26.5) |
| 1000–<10,000 | 156 (21.5) | 84 (22.2) |
| ≥10,000 | 345 (47.5) | 194 (51.3) |
| Missinga | 5 | 5 |
| Weight/age (CDC z-score) | ||
| ≤2SD from the mean | 118 (16.2) | 60 (15.8) |
| ±2 SD from the mean | 601 (82.4) | 318 (83.7) |
| >2SD above the mean | 10 (1.4) | 2 (0.5) |
| Missinga | 2 | 3 |
| Height/age (CDC z-score) | ||
| ≤2 SD from the mean | 148 (20.4) | 74 (19.5) |
| ±2 SD from the mean | 574 (79.2) | 304 (80.2) |
| >2 SD above the mean | 3 (0.4) | 1 (0.3) |
| Missinga | 6 | 4 |
| BMI percentile | ||
| <5th percentile | 68 (9.4) | 42 (11.2) |
| 5th<95th percentile | 615 (84.8) | 321 (85.4) |
| ≥95th percentile | 42 (5.8) | 13 (3.4) |
| Missinga | 6 | 7 |
a
Missing values are not included in percentages.
QR, quartile range represents the 25th and 75th quartile for the population; SD, standard deviation; OI, opportunistic infection; ARV, antiretroviral; PI, protease inhibitor; HAART, highly active antiretroviral therapy; NNRTI, nonnucleoside reverse transcriptase inhibitor; BMI, body mass index.