Table 2.
Proportion of HIV-Infected Children Reporting Opportunistic and Other Infections Prior to Enrollment in NISDI and PACTG
| |
NISDIa |
PACTG 219C3 |
||
|---|---|---|---|---|
| Category | N=731 | Percent (95% CI)b | N=2767 | Percent (95% CI)b |
| Overall first infections | 568 | 77.7 (74.7–80.7) | Not reported | |
| Bacterial pneumonia | 384 | 52.5 (48.9–56.2) | 698 | 25.2 (23.6–26.8) |
| Oral candidiasis | 212 | 29.0 (25.7–32.3) | 761 | 27.5 (25.8–29.2) |
| Varicella | 161 | 22.0 (19.0–25.0) | 395 | 14.3 (13.0–15.6) |
| Tuberculosis | 65 | 8.9 (6.8–11.0) | 17 | 0.6 (0.3–0.9) |
| Herpes zoster | 63 | 8.6 (6.6–10.6) | 280 | 10.0 (9.0–11.2) |
| Pneumocystis jiroveci | 61 | 8.3 (6.3–10.3) | 79 | 2.9 (2.2–3.5) |
| Diarrhea, proven | 56 | 7.7 (5.7–9.6) | 104 | 3.8 (3.1–4.5) |
| Molluscum contagiosum | 56 | 7.7 (5.7–9.6) | 151 | 5.5 (4.6–6.3) |
| Abscess, bacterial | 48 | 6.6 (4.8–8.4) | 5 | 0.2 (0.0–0.3) |
| Bacteremia/septicemia | 48 | 6.6 (4.8–8.4) | 220 | 8.0 (6.9–9.0) |
| Dermatophyte infections | 46 | 6.3 (4.5–8.1) | 422 | 15.3 (13.9–16.6) |
| Urinary tract infections | 44 | 6.0 (4.3–7.7) | 68 | 2.5 (1.9–3.0) |
| Lymphadenitis | 40 | 5.5 (3.8–7.1) | 11 | 0.4 (0.2–0.6) |
| Lymphoid interstitial pneumonitis | 39 | 5.3 (3.7–7.0) | 325 | 11.8 (10.6–13.0) |
| Herpes simplex | 27 | 3.7 (2.3–5.1) | 24 | 0.9 (0.5–1.2) |
| Bacterial meningitis | 23 | 3.1 (1.9–4.4) | 13 | 0.5 (0.2–0.7) |
| Viral hepatitis | 15 | 2.1 (1.0–3.1) | 60 | 2.2 (1.6–2.7) |
| Cytomegalovirus not retinitis | 11 | 1.5 (0.6–2.4) | 49 | 1.8 (1.3–2.3) |
| Esophageal/pulmonary candidiasis | 10 | 1.4 (0.5–2.2) | 39 | 1.4 (1.0–1.9) |
| Toxoplasmosis (CNS) | 9 | 1.2 (0.4–2.0) | 5 | 0.2 (0.0–0.3) |
| Cytomegalovirus retinitis | 6 | 0.8 (0.2–1.5) | 10 | 0.4 (0.1–0.6) |
| Measles | 5 | 0.7 (0.1–1.3) | 5 | 0.2 (0.0–0.3) |
a
NISDI also reported three cases of progressive multifocal leukoencephalopathy, two cases of bacterial osteomyelitis, and one each of Cryptosporidium and encephalitis.
b
Higher reporting of specific infections between cohorts shown by bolded nonoverlapping intervals.