Table 3.

Overall Incidence Rates of First-Time Infections for Categories with Four or More First Events Among Patients Enrolled in NISDI Compared with PACTG 219C

	NISDIa			PACTG 219C3
Category	Incident events	Person Years	IR of events/100 person years (95% CI)	Incident events	Person Years	IR of events/100 person years (95% CI)	pb
Overall first infectionsc	383	1633	23.45 (21.10–25.80)	—	—	—
Bacterial pneumonia	170	2174	7.82 (6.64–8.99)	123	5726	2.15 (1.79–2.56)	<0.001
Varicella	71	2385	2.98 (2.28–3.67)	29	6623	0.44 (0.29–0.63)	<0.001
Dermatophyte infections	69	2409	2.86 (2.19–3.54)	57	6483	0.88 (0.67–1.14)	<0.001
Herpes simplex virus	60	2440	2.46 (1.84–3.08)	11	7807	0.14 (0.07–0.25)	<0.001
Herpes zoster	45	2460	1.83 (1.29–2.36)	77	6925	1.11 (0.88–1.39)	0.02
Abscess, bacterialc	37	2448	1.51 (1.02–2.00)	—	—	—
Oral candidiasis	36	2466	1.46 (0.98–1.94)	52	5576	0.93 (0.70–1.22)	0.06
Molluscum contagiosum	31	2461	1.26 (0.82–1.70)	23	7392	0.31 (0.20–0.47)	<0.001
Lymphadenitis	22	2495	0.88 (0.51–1.25)	7	7849	0.09 (0.04–0.18)	<0.001
Urinary tract infection	19	2509	0.76 (0.42–1.10)	27	7660	0.35 (0.23–0.51)	0.03
Infectious diarrhea	18	2497	0.72 (0.39–1.05)	9	7552	0.12 (0.05–0.23)	<0.001
P. jiroveci pneumonia	9	2526	0.36 (0.12–0.59)	7	7668	0.09 (0.04–0.19)	0.03
Lymphoid interstitial pneumonitis	7	2533	0.28 (0.07–0.48)	6	6889	0.09 (0.03–0.19)	0.09
Bacterial meningitisc	7	2522	0.28 (0.07–0.48)	—	—	—
Tuberculosis (TB)	7	2523	0.28 (0.07–0.48)	<4	—	—
Viral hepatitis	6	2525	0.24 (0.05–0.43)	11	7729	0.14 (0.07–0.25)	0.37
Bacteremia/septicemia	5	2529	0.20 (0.02–0.37)	25	7192	0.35 (0.22–0.51)	0.18
CMV not retinitisc	4	2534	0.16 (0.0–0.31)	—	—	—

^aNISDI reported <4 events for toxoplasmosis (3), non-TB mycobacteria (2), esophageal or pulmonary candidiasis (2), Cryptosporidium (2)^c, progressive multifocal leukoencephalopathy (2)^c, CMV retinitis (1), encephalitis (1)^c, septic arthritis, bacterial (1)^c.

^bFisher's exact test.

^cNot reported in PACTG 219C.³

IR, incidence rate; CMV, cytomegalovirus.