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. Author manuscript; available in PMC: 2013 Feb 24.
Published in final edited form as: Chem Biol. 2012 Feb 24;19(2):218–227. doi: 10.1016/j.chembiol.2011.12.016

Figure 3. The methylcitrate cycle is required for the metabolism of cholesterol-derived propionate.

Figure 3

The indicated mutants were grown in the presence of 0.1% glycerol (A, E), 0.01% cholesterol (B, F), or 0.01% cholesterol and 0.1% glycerol (C, G) as primary carbon sources. Vitamin B12 supplementation (D, H) allowed all mutants to grow using cholesterol. Optical density was measured at the indicated time points and is plotted on a log scale. prpDC mutants were generated in the H37Rv strain, and icl1/2 mutants were derived from the Erdman strain.