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A. Mutations caused by 8-oxoguanine and repair mediated by MutY/MUTYH and MutM/hOGG1. B. Proposed mechanism for adenine glycosylase activity of MutY based on kinetic isotope effect studies and X-ray crystallography. The residue that participates in activating the water nucleophile remains uncertain, and thus, is not shown in this mechanism.
