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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Eur J Oral Sci. 2011 Dec;119(Suppl 1):329–337. doi: 10.1111/j.1600-0722.2011.00860.x

Fig. 1.

Fig. 1

Apoptosis [determined using terminal deoxynucleotidyl transferase (TdT)-mediated biotin–dUTP nick-end labelling (TUNEL)] in day-5 mouse maxillary first molars from wild-type (A, B), enamelin (Enam) heterozygous (C, D), and Enam null (E, F) mice. Panels on the right (B, D, F) detail the apoptotic staining in the ameloblast layer of the central cusp tip. Arrowheads in panel F indicate apoptotic nuclei apparently embedded in the mineral layer. Am, ameloblasts; De, dentin; En, enamel; Od, odontoblasts; P, pulp. Bars = 100 µm. Ameloblasts are in the secretory stage of amelogenesis.