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. Author manuscript; available in PMC: 2012 Mar 3.
Published in final edited form as: Adv Immunol. 2006;92:71–117. doi: 10.1016/S0065-2776(06)92002-1

Figure 1.

Figure 1

Schematic illustration of the segregation of a recessive allele a predisposing to disease in an F2 intercross design and a backcross design. The co-segregation with the flanking genetic markers M1, with alleles 1 and 2, and M2, with alleles, 1 and 2, is indicated. The genotype at the disease locus can easily be deduced using these flanking markers.