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. Author manuscript; available in PMC: 2012 Mar 3.
Published in final edited form as: Adv Immunol. 2006;92:71–117. doi: 10.1016/S0065-2776(06)92002-1

Figure 3.

Figure 3

Schematic representation of “two essential gene family”’ concept for the development of autoimmune disease. Arrows represent modulatory factors affecting either the immune system or the target organ.