Figure 2.

HSF-1 acts in multiple tissues to regulate life span. (A) Life span of wild-type (N2) or transgenic animals expressing marker gene (myo-2::gfp) alone or in combination with let-858::hsf-1 or let-858::hsf-1Δ (encoding residues 290-671 of C. elegans HSF-1). (B) Life spans of transgenic animals expressing marker alone (myo-2::gfp) or in combination with hsf-1 in body-wall muscle (unc-54::hsf-1), intestine (vha-6::hsf-1), or nervous system (F25B5.3::hsf-1). Data are representative of experiments with two independent transgenic lines. No significant differences were noted between the duplicate lines. The data reported represent two independent trials that yielded similar results. In each case, the appropriate control was tested in parallel in the same experiment. For statistical analysis, see Table 2.