Table 4.
Effect of chaperone RNAi on life span of wild-type (N2) and age-1(hx546) animals at 25°C
| Family | Adult lifespan (d) mean ± SEM | N | Control lifespan, % | P value | |
|---|---|---|---|---|---|
| N2 | |||||
| vector | 14.1 ± 0.3 | 65 | |||
| hsp-16 | sHsp | 14.3 ± 0.3 | 69 | 101 | > 0.05 |
| sip-1 | 14.2 ± 0.3 | 68 | 100 | > 0.05 | |
| T05C3.5 | Hsp40/DnaJ | 14.6 ± 0.2 | 76 | 103 | >0.05 |
| F39B10.2 | 14.6 ± 0.2 | 79 | 103 | > 0.05 | |
| hsp-1 | 14.6 ± 0.3 | 75 | 103 | > 0.05 | |
| C30C11.4 | Hsp70 | 14.3 ± 0.2 | 85 | 101 | > 0.05 |
| C12C8.1 | 14.2 ± 0.3 | 79 | 100 | > 0.05 | |
| daf-21 | Hsp90 | 14.6 ± 0.2 | 84 | 103 | > 0.05 |
| Age-1(hx546) | |||||
| vector | 26.7 ± 0.4 | 83 | |||
| hsp-16 | sHsp | 24.5 ± 0.4 | 107 | 92 | < 0.05 |
| sip-1 | 24.1 ± 0.4 | 102 | 90 | < 0.01 | |
| T05C3.5 | Hsp40/DnaJ | 26.3 ± 0.5 | 95 | 99 | > 0.05 |
| F39B10.2 | 26.5 ± 0.5 | 82 | 100 | > 0.05 | |
| hsp-1 | 23.4 ± 0.6 | 91 | 88 | < 0.001 | |
| C30C11.4 | Hsp70 | 23.6 ± 0.3 | 112 | 88 | < 0.001 |
| C12C8.1 | 24.1 ± 0.4 | 111 | 90 | < 0.001 | |
| daf-21 | Hsp90 | 23.1 ± 0.4 | 104 | 87 | <0.001 |