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. 2012 Feb 1;32(5):1517–1527. doi: 10.1523/JNEUROSCI.2895-11.2012

Figure 3.

Figure 3.

Ablation of Chd4 impairs the ability of Schwann cells to myelinate. Electron micrographs of sciatic nerve from control (A) and Chd4 cko (B) mice at P30. Magnification of myelin wraps show normal periodicity (C, inset). Scale bar, 0.1 μm. Scatter plot analysis of g ratio and axon diameter (D) shows the axon diameter is similar between genotypes; however, thinner myelin wraps axons of all diameters in Chd4 KO mice. Quantitation of the rate of dysmyelination indicates 24% of large-caliber axons contain abnormalities in myelination (E). Examples include amyelination, frayed myelin (F), or disorganized Schwann cell structures containing myelin debris (G). Scale bar: 1 and 2 μm, respectively. In addition, macrophage infiltration is characteristic of P30 nerve (H). Scale bar, 2 μm.