. Author manuscript; available in PMC: 2012 Sep 15.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Jun 28;21(18):5528–5532. doi: 10.1016/j.bmcl.2011.06.099

Table 3.

Average IC₅₀ (from n independent experiments in μM) of selected arylsulfonamide HIF-1 pathway inhibitors as established in the HRE-luciferase assay. Molecular weight of compounds and predicted miLog P values (http://www.molinspiration.com/) are also shown.

Name	Mol. Wt.	Log P	IC₅₀ (n=)	Std. Error	95% CI¹
KCN1	465.571	5.2	0. 593 (21)	0.063	(0.470, 0.716)
KCN 49	582.438	6.957	0.508 (5)	0.118	(0.277, 0.739)
KCN 60	471.619	5.798	1.267 (5)	0.127	(1.018, 1.516)
KCN 63	453.589	6.133	0.656 (5)	0.158	(0.346, 0.966)
KCN 65	454.419	6.258	0.731 (5)	0.191	(0.357, 1.105)
KCN 66	430.526	4.933	0.532 (5)	0.084	(0.367, 0.697)
KCN 67	445.581	4.62	0.672 (6)	0.177	(0.325, 1.019)
KCN 68	445.581	5.015	1.011 (6)	0.312	(0.399, 1.623)

Confidence Interval