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. Author manuscript; available in PMC: 2012 Dec 22.
Published in final edited form as: J Med Chem. 2011 Nov 23;54(24):8471–8489. doi: 10.1021/jm201018g

Scheme 5.

Scheme 5

Synthesis of benzofuran analoguesa

R1 = phenyl (16a), cycloheptyl (16b), isopropyl (16c), butyl (16d), cyclohexyl (16e), cyclopentyl (16f)

aReagents and Conditions: (a) R1NH2, ZnCl2, NaCNBH3, r.t., 2 h; (b) 3,4-dimethoxybenzenesulfonyl chloride, Et3N, DCM, r.t., 14 – 42%.