Table 1. Comparison of genetically engineered mouse models.

Cre Driver Line/Viral Driver Construct	Targeted Genes	Tumor Histology	Core Pathway Mutation/Dysregulation	Tumor Initiating Cell	Tumor Location	Expression Subgroups	Reference
GFAP-CreER (induction at 4wk)	Pten, Trp53	HGA	mutation	adult NPC or astrocyte	proliferative and non-proliferative zones	PN, Prolif, Mes	42
	Pten, Trp53, Rb1	HGA	mutation
	Rb1, Trp53	HGA, PNET, ONB	dysregulation			NA
Adeno-Cre (injected into lateral ventricle)	Pten, Trp53	HGA	dysregulation	postnatal SVZ cells	SVZ	NA	43
	Pten, Trp53, Rb1	PNET	NA
	Rb1, Trp53	PNET	NA
GFAP-Cre	Trp53	HGA, MB	dysregulation	early NPC or OPC	proliferative zones	NA	46
Adeno-Cre (injected into striatum at 3mo)	EGFR VIII, Cdkn2a, Pten	HGA	NA	glial cells	striatum	NA	47
RCAS-PDGFB +/− RCAS-Cre (injected into SVZ, cortex or cerebellum of Nestin-tv-a mice at 4wk)	PDGFB, Cdkn2a, Pten	HGA	NA	nestin positive cells	proliferative and non-proliferative zones	NA	48
GFAP-Cre	Nf1, Trp53	HGA	dysregulation	early SVZ cells	SVZ	NA	52
GFAP-Cre	Nf1, Trp53, Pten	HGA	dysregulation	early SVZ cells	SVZ	NA	51
Nestin-CreER (induction at 4wk)	Nf1, Trp53	HGA	NA	adult NPC	proliferative zones	NA	53
	Nf1, Trp53, Pten	HGA	NA
Adeno-Cre (injected into SVZ at 4wk)	Nf1, Trp53	HGA	NA	adult SVZ cells	SVZ	NA	53
	Nf1, Trp53, Pten	HGA	NA
Retroviral PDGFB/Cre (injected into subcortical white matter at 6wk)	PDGFB, Pten	HGA	NA	adult OPC	white matter	PN	61
	PDGFB, Pten, Trp53	HGA	NA
GFAP-Cre	Nf1, Trp53	HGA	NA	early OPC	proliferative zones	PN	63

Abbreviations: SVZ – subventricular zone; HGA – high-grade glioma; PNET – primitive neuroectodermal tumor; ONB – olfactory neuroblastoma; MB – medulloblastoma; NA – not assessed; NPC – neural progenitor cell; OPC – oligodendrocyte progenitor cell; PN – Proneural; Prolif – Proliferative; Mes – Mesenchymal