Table 2. Targeting of CAIX by small molecules in preclinical models of human cancer.

Tumor Model [citation]	Inhibitor	Effect
LS174T human colon carcinoma [109]	fluoro-acetazolamide	bound to xenograft tissue; no significant effect on tumor growth
SK-RC-52 human renal cell carcinoma [109]	albumin-acetazolamide	significant reduction in tumor growth
HT-29 human renal cell carcinoma [110]	bis sulfonamide	tumor-specific accumulation; effect on tumor growth not measured
HT-29 human renal cell carcinoma [111]	fluorescent sulfonamide	tumor-specific accumulation; effect on tumor growth not measured
4T1 metastatic mouse breast cancer [23]	fluorescent sulfonamide	significant inhibition of tumor growth
4T1 metastatic mouse breast cancer [23, 102]	ureido sulfonamides	inhibition of experimental lung metastases
4T1 metastatic mouse breast cancer [23, 103]	glycosyl coumarins	inhibition of experimental lung metastases; inhibition of primary tumor growth
MDA-MB-231 LM2-4 lung metastatic breast cancer [23]	ureido sulfonamides	inhibition of primary tumor growth
HT-29 human renal cell carcinoma [84]	indanesulfonamide	inhibition of primary tumor growth; synergy with radiotherapy