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Caspase-3 deficiency inhibited MPTP-induced apoptosis in the substantia nigra in mice. MPTP administration induced apoptosis in the substantia nigra of wild-type (WT) mice, as judged by double staining for TUNEL (green) and tyrosine hydroxylase (TH, red), at 24 h after the inception of MPTP injections. In caspase-3 knockout (KO) mice, however, MPTP failed to induce apoptosis in the substantia nigra.
