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. Author manuscript; available in PMC: 2012 Mar 4.
Published in final edited form as: Biochem Biophys Res Commun. 2010 Oct 19;402(2):312–318. doi: 10.1016/j.bbrc.2010.10.023

Fig. 3.

Fig. 3

Caspase-3 deficiency prevented MPTP-induced bradykinesia and reduction in tyrosine hydroxylase expression in mice. At 7 days after MPTP administration, the tail suspension test showed prolonged immobility time in wild- type (WT) mice compared to vehicle alone (A). In contrast, MPTP did not affect duration of immobility in caspase-3 knockout (KO) mice. Immunoblot (B) and immunohistochemical (C) analyses revealed that the protein expression of tyrosine hydroxylase (TH) was markedly decreased in the nigra-striatum of wild-type, but not caspase-3 knockout, mice at 7 days after MPTP administration compared with vehicle alone. The protein expression of GAPDH was not altered by MPTP or caspase-3 deficiency. n=4 per group. *p<0.05, **p<0.01, ***p<0.001.