Table 3.
The predicted transcription factors binding to fatty acid-responsive element in the promoter of the gene involved in Hcy metabolism
| Gene | GeneID | Transcript | Factor | Name(s) | Chrom | Start | End |
|---|---|---|---|---|---|---|---|
| MTR | 4548 | NM_000254 | MA0066 | PPARG | chr1 | 236,956,831 | 236,956,850 |
| MTR | 4548 | NM_000254 | MA0061 | NF-kappaB | chr1 | 236,958,560 | 236,958,569 |
| HHCY | 191 | NM_000687 | MA0061 | NF-kappaB | chr20 | 32891257 | 32891266 |
| HHCY | 191 | NM_000687 | M00242 | PPARalpha:RXRalpha | chr20 | 32891807 | 32891826 |
| HHCY | 191 | NM_000687 | M00964 | PXR, CAR, LXR, FXR | chr20 | 32892802 | 32892813 |
| HHCY | 191 | NM_000687 | T00720 | RAR-gamma | chr20 | 32891787 | 32891797 |
| HHCY | 191 | NM_000687 | MA0074 | RXRA::VDR | chr20 | 32891381 | 32891395 |
| CSE | 1491 | NM_153742 | M00774 | NF-kappaB | chr1 | 70876211 | 70876222 |
| CSE | 1491 | NM_153742 | M00762 | PPAR, HNF-4, COUP, | chr1 | 70875793 | 70875805 |
| CSE | 1491 | NM_153742 | M00518 | PPARalpha:RXRalpha | chr1 | 70876539 | 70876552 |
| CSE | 1491 | NM_153742 | MA0065 | PPARG::RXRA | chr1 | 70876537 | 70876553 |
| CSE | 1491 | NM_153742 | MA0074 | RXRA::VDR | chr1 | 70875356 | 70875369 |
| CSE | 1491 | NM_153742 | T01331 | RXR-alpha | chr1 | 70876645 | 70876657 |
| CBS | 875 | NM_000071 | MA0061 | NF-kappaB | chr21 | 44496816 | 44496825 |
| CBS | 875 | NM_000071 | T00694 | PPAR-alpha | chr21 | 44496841 | 44496851 |
| CBS | 875 | NM_000071 | MA0073 | RREB1 | chr21 | 44496183 | 44496202 |
| CBS | 875 | NM_000071 | MA0074 | RXRA::VDR | chr21 | 44496362 | 44496376 |
| CBS | 875 | NM_000071 | T01349 | RXR-beta | chr21 | 44496925 | 44496932 |
| MAT1A | 4143 | NM_000429 | T05257 | CAR2:RXR-alpha | chr10 | 82051245 | 82051257 |
| MAT1A | 4143 | NM_000429 | M00631 | FXR/RXR-alpha | chr10 | 82050669 | 82050682 |
| MAT1A | 4143 | NM_000429 | MA0061 | NF-kappaB | chr10 | 82049620 | 82049629 |
| MAT1A | 4143 | NM_000429 | MA0105 | NFKB1 | chr10 | 82049504 | 82049514 |
| MAT1A | 4143 | NM_000429 | T02529 | PPAR-gamma1 | chr10 | 82051368 | 82051378 |
| MAT1A | 4143 | NM_000429 | MA0074 | RXRA::VDR | chr10 | 82050026 | 82050040 |
| MAT1A | 4143 | NM_000429 | T01331 | RXR-alpha | chr10 | 82050924 | 82050936 |
| MTHFR | 4524 | NM_005957 | MA0066 | PPARG | chr1 | 11866220 | 11866239 |
| MTHFR | 4524 | NM_005957 | T05313 | FXR:RXR-alpha | chr1 | 11867028 | 11867042 |
| MTHFR | 4524 | NM_005957 | M00774 | NF-kappaB | chr1 | 11866612 | 11866623 |
| MTHFR | 4524 | NM_005957 | M00518 | PPARalpha:RXRalpha | chr1 | 11867952 | 11867966 |
| MTHFR | 4524 | NM_005957 | MA0065 | PPARG::RXRA | chr1 | 11867331 | 11867347 |
| MTHFR | 4524 | NM_005957 | T02529 | PPAR-gamma1 | chr1 | 11867417 | 11867427 |
| MTHFR | 4524 | NM_005957 | M00964 | PXR, CAR, LXR, FXR | chr1 | 11866787 | 11866798 |
The predicted transcription factors (RXR-alpha) binding to n-3 PUFA-RE in the promoter of MTHFR, CSE, and MAT using web based software Mapper: http://genome.ufl.edu/mapper/.