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. 2012 Feb 8;8:10. doi: 10.1186/1744-8069-8-10

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Copyright ©2012 Cunha et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PI3Ks mediates the peripheral antinociceptive action of KOR agonists. (A-B) Mechanical hyperalgesia in rats was induced by an ipl. injection of PGE₂(100 ng/paw)_.The antinociceptive effect of U50488 (10 μg/paw, 2 h after PGE₂injection) after PGE₂-induced hyperalgesia was prevented by a pretreatment (30 min) with non-selective inhibitors of PI3Ks: wortmannin (3 μg/paw) or LY294002 (10 μg/paw). Data are expressed as the mean ± S.E.M. of 5-6 animals per group. * Indicates statistical significance compared to the vehicle group. # Indicates statistical significance compared to the U50488 treated group. P < 0.05, one-way ANOVA, followed by the Bonferroni correction.