Table 1.
ABR thresholds (± SD) in the different groups at baseline and 7 and 21 days later.
| Experimental group | Set A (SA 350 mg/kg, F 100 mg/kg) | Set B (SA 300 mg/kg, F 50 mg/kg) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Threshold baseline (dB) | Threshold day 7 (dB) | Threshold shift | n | Threshold baseline (dB) | Threshold day 7 (dB) |
Threshold shift | Threshold day 21 (dB) | Threshold shift | |
| I: Saline + noise exposure | 7 | 52.1 ± 10.4 | 82.1 ± 17.5 | 34.3 ± 17.7 | 4 | 62.5 ± 2.9 | 90.0 ± 16.8 | 27.5 ± 18.9 | 91.3 ± 18.9 | 28.8 ± 19.3 |
| II: SA only + noise exposure | 5 | 48.0 ± 9.0 | 73.0 ± 18.2 | 25.0 ± 17.0 | 6 | 59.2 ± 5.8 | 78.3 ± 16.0 | 19.2 ± 13.9 | 76.7 ± 15.4 | 15.8 ± 10.2 |
| III: F only + noise exposure | 8 | 55.0 ± 7.1 | 76.9 ± 17.1 | 21.9 ± 13.4 | 6 | 59.2 ± 5.8 | 80.0 ± 8.4 | 20.8 ± 7.4 | 81.7 ± 11.3 | 22.5 ± 16.0 |
| IV: SA + F + noise exposure | 8 | 51.9 ± 12.2 | 88.8 ± 14.8 | 38.8 * ± 19.0 | 6 | 59.2 ± 5.8 | 87.5 ± 15.7 | 28.3 * ± 11.7 | 90.0 ± 16.1 | 30.0 * ± 13.4 |
| V: SA + F no noise exposure | 3 | 50.0 ± 8.7 | 58.3 ± 5.8 | 6.7 ± 5.8 | 6 | 60.8 ± 3.8 | 68.3 ± 15.4 | 10.0 ± 12.3 | 63.3 ± 5.8 | 2.5 ± 4.2 |
Different drug doses were administered to the two sets (A and B) of mice.
* There is no significant difference in threshold shift between the mice receiving all 3 agents (group IV; SA + Furosemide + noise) and those receiving saline before noise (group I). (P > 0.6)
SA: salicylic acid, F: furosemide, dB: decibel, n: number of mice