Table 2.

Gene ontology results from genes downregulated during primary infestation.

Cluster	Term	PValue
Nucleotide metabolism	Cell morphogenesis	0.039
and transcription	DNA binding	0.020
	Positive regulation of biosynthetic process	0.025
	Positive regulation of cellular biosynthetic process	0.022
	Positive regulation of gene expression	0.046
	Positive regulation of macromolecule biosynthetic process	0.022
	Positive regulation of macromolecule metabolic process	0.042
	Positive regulation of nitrogen compound metabolic process	0.014
	Positive regulation of nucleobase, nucleoside, nucleotide and nucleic- acid metabolic process	0.010
	Positive regulation of RNA metabolic process	0.032
	Positive regulation of transcription	0.036
	Positive regulation of transcription from RNA polymerase II- promoter	0.025
	Positive regulation of transcription, DNA-dependent	0.032
	Regulation of RNA metabolic process	0.025
	Regulation of transcription	0.046
	Regulation of transcription from RNA polymerase II promoter	0.027
	Regulation of transcription, DNA-dependent	0.027
	Sequence-specific DNA binding	0.018
	Tissue morphogenesis	0.026
SEFIR domain	IPR013568:SEFIR (IL-17R domain)	0.026

Significant gene ontology terms from genes downregulated at any time point during primary infestation of mice with I. scapularis nymphs are shown grouped into clusters based on the functional annotation clustering tool available from DAVID.