Table 3.
Gene ontology results from genes upregulated during secondary infestation.
| Cluster | Terms | PValue | Cluster | Terms | PValue |
|---|---|---|---|---|---|
| Putative | Disulfide bond | 0.00002 | Immune cell | Positive regulation of signal transduction | 0.0032 |
| Secreted | Signal peptide | 0.0038 | signaling and | Positive regulation of cell communication | 0.005 |
| Signal | 0.0043 | activation | Four-helical cytokine, core | 0.0061 | |
| Glycoprotein | 0.013 | Regulation of cell activation | 0.0063 | ||
| Cytokine | Immune response | 0.00001 | Regulation of peptidyl-tyrosine phosphorylation | 0.0071 | |
| Cytokine | 0.00026 | Regulation of leukocyte proliferation | 0.008 | ||
| Cytokine activity | 0.0013 | Regulation of T cell activation | 0.008 | ||
| Extracellular space | 0.0019 | Positive regulation of peptidyl-tyrosine phos. | 0.011 | ||
| Cytokine-cytokine receptor interaction | 0.0054 | Regulation of lymphocyte activation | 0.014 | ||
| Hematopoietic | Hematopoietic cell lineage | 0.0011 | Regulation of leukocyte activation | 0.014 | |
| lineage | T-cell | 0.0032 | Regulation of hematopoiesis by cytokines | 0.019 | |
| Regulation of hematopoiesis by cytokines | 0.019 | Regulation of mononuclear cell proliferation | 0.019 | ||
| Inflammation | Inflammatory response | 0.027 | Regulation of lymphocyte proliferation | 0.019 | |
| Defense response | 0.027 | Regulation of protein kinase cascade | 0.02 | ||
| Chemotaxis | Chemotaxis | 0.0024 | Positive regulation of T cell activation | 0.03 | |
| Locomotory behavior | 0.0024 | Regulation of cellular localization | 0.033 | ||
| Taxis | 0.0024 | Positive regulation of protein kinase cascade | 0.033 | ||
| Leukocyte adhesion | 0.017 | Regulation of protein modification process | 0.034 | ||
| Cell chemotaxis | 0.026 | Regulation of cellular protein metabolic process | 0.034 | ||
| Leukocyte chemotaxis | 0.026 | Positive regulation of immune system process | 0.034 | ||
| Neutrophil chemotaxis | 0.026 | Regulation of chemokine production | 0.039 | ||
| Leukocyte migration | 0.032 | Regulation of chemokine biosynthetic process | 0.039 | ||
| Cell surface | Monocyte and its Surface Molecules | 0.0025 | Positive regulation of cell activation | 0.045 | |
| molecules | Cell adhesion molecules (CAMs) | 0.0071 | Positive regulation of protein modification process | 0.047 | |
| External side of plasma membrane | 0.01 | Regulation of T cell proliferation | 0.047 | ||
| Cell surface | 0.021 | Tyrosine | Regulation of peptidyl-tyrosine phosphorylation | 0.0071 | |
| T-cell regulation | Positive regulation of T cell activation | 0.03 | phosphorylation | Positive regulation of peptidyl-tyrosine phos. | 0.011 |
| Regulation of cellular localization | 0.033 | Leukocyte | Monocyte and its Surface Molecules | 0.0025 | |
| Regulation of alpha-beta T cell differentiation | 0.039 | adhesion | Cell adhesion molecules (CAMs) | 0.0071 | |
| Positive regulation of alpha-beta T cell diff. | 0.039 | Neutrophil and Its Surface Molecules | 0.0082 | ||
| Sushi domain | domain:Sushi 2 | 0.036 | Leukocyte adhesion | 0.017 | |
| domain:Sushi 1 | 0.036 | Adhesion Molecules on Lymphocyte | 0.019 | ||
| domain:EGF-like | 0.036 | Natural killer cell mediated cytotoxicity | 0.021 | ||
| Activation | Propeptide:Activation peptide | 0.048 | |||
| peptide | |||||
Significant gene ontology terms from genes upregulated at any time point during secondary infestation of mice with I. scapularis nymphs are shown grouped into clusters based on the functional annotation clustering tool available from DAVID.