Figure 9.

LGA_pdblist functional side-chain differences between NDM-1 and other B1 MBLs. Using 3q6x_A as a reference, functional side-chain differences are shown of NDM-1 against IMP-1, VIM-2,4 and ccrA. Measurements are taken only for instances where the residue-residue correspondence for NDM-1 to the other MBLs match, and only then for those with functional sidechains (e.g., alanine, glycine are ignored) [44]. Coloring is from green (< 2Å) to red (< 8Å), with gray indicating no match. Notable regions of B1 MBLs are highlighted, and include the zinc binding region, the L10 ligand-binding loop and the K211 residue noted in Figure 8. Additional annotations show areas where side-chains consistently differ from 3q6x_A and either other NDM-1 structures or other B1 MBLs (e.g., flap region).