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. 2011 Nov 16;32(3):525–536. doi: 10.1038/jcbfm.2011.159

Figure 3.

Figure 3

Transcriptional stimulation of the Abcc8 promoter by hypoxia and by coexpression of hypoxia-inducible factor 1α (HIF1α). Relative luciferase activity of chicken β-actin promoter (Actin), erythropoietin enhancer (EpoE), and −521/+62 (numbers relative to the transcription start site) region of human Abcc8 promoter (Abcc8), each tested with cotransfection of empty vector (CTR), coexpression of HIF1α, after exposure to hypoxia alone, and after exposure to hypoxia plus cotransfection with HIF1α; n=5 for each promoter; *P<0.05; **P<0.01; ***P<0.001.