Figure 2.

Glutamate and -serine increase lumen diameter in the brain slice arterioles. (A) Combinations of glutamate and -serine as low as 10 μmol/L each agonist causes significant middle cerebral artery (MCA) dilation. ^*P<0.05 compared with glutamate only group using a t-test. (B) The combination of glutamate and -serine causes significant dilation of penetrating cortical arterioles in cortical slices in the presence and absence of the neuronal excitability blocker, tetrodotoxin (TTX). Data are presented as mean values±s.d. of 14 (control) or 18 (TTX group) brain slices and were analyzed by two-way analysis of variance (ANOVA) for repeated measures and Bonferroni post-hoc test.