Figure 3.

Sensitivity analysis of the model relatively to the parameters V_gt^g (A), V_nt (B), and V_gtⁿ (C). The thick line represents the simulated data for (V_tca^g=0.06, V_tcaⁿ=0.56, V_x^g=V_xⁿ=0.57, and V_nt=0.17 μmol/g per minute), using a typical arterial input function. The thinner lines represent each time a step of 10% increase or decrease in the corresponding parameter value. The sensitivity analysis shows that the curve is predominantly driven by the composite flux V_gt^g, characterizing the label input in the glial glutamate C5 position.