Table 1.

Designs

CRM	Usual CRM two-stage design making no use of information on grades.
CRMG(1,0)	CRM two-stage design using information on grades only in first stage.
CRMG(1,1)	CRM two-stage design using grades in both stages. For the second stage, the association parameter between intermedi- ary toxicities and DLTs is known.
CRMG(1,2)	CRM two-stage design using grades in both stages. For the second stage, the association parameter between interme- diary toxicities and DLTs is estimated by maximizing the appropriate likelihood.