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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Front Biosci. 2012 Jan 1;17:805–823. doi: 10.2741/3958

Figure 2.

Figure 2

STIM1 domains. This model (not drawn to scale) depicts the critical domains of STIM1 with its N-terminal in the ER lumen and the C-terminal in the cytosol. The amino acids that span individual domain are shown within parentheses. The lysine (K) residues, critical for TRPC channel gating (shown in orange), lie within the poly-K region in the cytoplasmic domain on STIM1. The cytoplasmic domain of STIM1 also contains the overlapping Orai1 activating regions (CAD/SOAR). Shown in blue are the residues that are glycosylated (N-terminal) or phosphorylated on serine (C-terminal). Abbreviations - c/hEF hand (canonical/hidden), SAM (sterile alpha motif), TM (trans membrane), CC1/2 (coiled-coil), ERM (Ezrin-Radixin-Moesin), CAD (CRAC activation domain), SOAR (STIM1 Orai activating region)