TABLE I.
| Max | CARB | DAR | METH | Muscle receptors | Urothelial receptors | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | Race | Sex | Wt. (kg) | History | (% KCl) | pEC50 | pKb | pKb | Total | M2 | M3 | Total | M2 | M3 |
| 70 | C | F | 108 | ICH | 133 | 7.07 | 9.3 | 175 | 112 | 27 | 14 7 | 98 | 9 | |
| 63 | C | F | 82 | SAH | 133 | 6.25 | 9.0 | 188 | 70 | 43 | 202 | 78 | 17 | |
| 59 | C | M | 101 | ICH | 183 | 6.49 | 8.6 | 950 | 574 | 269 | 131 | 81 | 13 | |
| 58 | C | M | 77 | SAH | 99 | 5.55 | 8.4 | 5.9 | 284 | 249 | 42 | 274 | 189 | 15 |
| 19 | C | M | 70 | MVA | 102 | 6.17 | 8.4 | |||||||
| 39 | C | M | 92 | CVA | 155 | 6.59 | 8.4 | 267 | 115 | 47 | 174 | 94 | 10 | |
| 39 | C | F | 76 | CB | 10 5 | 5.85 | 8.3 | 16 5 | 95 | 44 | 3 18 | 15 6 | 6 | |
| 4 | C | M | 14 | ANOXIA | 137 | 6.57 | 8.3 | 6.3 | 777 | 459 | 193 | 316 | 163 | 60 |
| 44 | C | F | 77 | MVA | 269 | 5.77 | 8.2 | 5.4 | ||||||
| 20 | C | M | 84 | HT | 83 | 6.94 | 8.2 | 6.1 | 531 | 313 | 157 | 277 | 146 | 44 |
| 25 | C | M | 89 | ANOXIA | 363 | 5.71 | 8.1 | 184 | 94 | 53 | 147 | 83 | 29 | |
| 61 | C | F | 72 | ICH | 195 | 5.99 | 8.0 | 5.7 | 290 | 190 | 72 | 229 | 218 | 27 |
| 58 | C | F | 99 | SAH | 124 | 6.05 | 8.0 | 5.6 | ||||||
| 44 | B | F | 118 | CB | 128 | 6.23 | 7.9 | |||||||
| 49 | C | M | 90 | HT | 155 | 6.21 | 7.9 | 207 | 113 | 31 | 400 | 179 | 30 | |
| 58 | C | M | 68 | CVA | 329 | 5.71 | 7.9 | |||||||
| 38 | C | F | 126 | CVA | 161 | 5.57 | 7.8 | 239 | 146 | 52 | 274 | 193 | 18 | |
| 46 | C | F | 55 | CVA | 122 | 6.13 | 7.8 | 6.0 | 277 | 182 | 75 | 171 | 103 | 17 |
| 59 | C | M | 98 | ICH | 133 | 6.60 | 7.7 | 637 | 371 | 126 | 495 | 350 | 74 | |
| 56 | H | F | 69 | CVA | 6.10 | 7.6 | ||||||||
| 34 | C | F | 60 | ICH | 114 | 6.66 | 7.6 | 286 | 146 | 76 | 146 | 88 | 13 | |
| 47 | C | M | 75 | ANOXIA | 107 | 5.28 | 7.5 | |||||||
| 69 | C | M | 64 | SDH | 117 | 5.13 | 7.4 | 6.5 | 363 | 185 | 64 | 225 | 151 | 25 |
| 70 | C | M | 73 | ICH | 148 | 6.19 | 7.2 | 5.6 | 391 | 275 | 82 | 344 | 199 | 37 |
Muscarinic receptor density is reported as fmoles/mg solubilized protein. CARB, carbachol; DAR, darifenacin; METH, methoctramine; ICH, intracerebral hemorrhage; SAH, sub-arachnoid hemorrhage; MVA, motor vehicle accident; CVA, cerebrovascular accident; CB, cerebral bleed; HT, head trauma; SDH, sub-dural hemorrhage.