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Characteristics of permeability markers used
| Drug | Structure | Molecular Formula | log P | pKa | BCS class |
|---|---|---|---|---|---|
| Antipyrine |
|
C11H12N2O (188.23 g/mol) | 0.38 | 1.4 | I (HP, HS) |
| Carbamazepine |
|
C15H12N2O (223.25 g/mol) | 2.45 | 14 | II (HP, LS) |
| Furosemide |
|
CH12Cl11N2O5S (330.74 g/mol) | 1.4 | 3.9 | IV (LP, LS) |
| Phenytoin |
|
C15H12N2O2 (252.27 g/mol) | 2.2 | 8.3 | II (HP, LS) |
HP…high permeability; LP…low permeability; HS…high solubility; LS…low solubility.
